The Infection game I came up with a while ago depends on a severe inbalance of blasters. Nerf SS would actually work for it if you can afford them.
Perhaps a good comparison here is with Airsoft; there are kids who run into the woods to shoot $30 springers, and then there are those who run milsim games a lot like military training activities with electric or gas powered replicas. We are the latter, and the kids with the Nerf SS's are the former, only difference being that the springers are half the price of the top of the line gas powered rifles, instead of 1/10th of the price.
As for the difficulty of making hits, you do have to consider the effects of low ranges on tactics. It would seem that all combat has to happen almost at sword combat range in order to get any hits with Nerf SS's, requiring perhaps slightly different player strategies and placing more emphasis on speed/movement.
For BBT, it falls somewhere in the middle between standard OHS and Nerf SS only OHS. The closer ranges than with standard CPS's has not had a huge effect on tactics, but the biggest change was not running out of water easily, thus being able to suppress more.
Not sure what else we can do in the way of gametypes. For common games like CTF or OHS, they can work almost as well with squirters as they do with high range/output CPS.
However, as I've found from hosting "light blasters only" (defined by me since I don't have enough of an armory to host AP or WW only) games, a fun mix of blasters is possible when range and mobility aren't the only thing that matter. I was duel wielding Max-D 3k's against someone with a Max-D 6k and we also had a Flash Flood in the mix. Games like these welcome blasters from anywhere, including literally almost all BBT's (or major ones) and old XP's. I'd draw the line at just under CPS 1000 performance, so the SS 300 and anything better than the Flash Flood would likely be prohibited. I need to draft some stricter definitions on what blaster classes are allowed, but having a limit only encourages everyone to try to bring their equipment to that limit. (i.e. Suddenly a CPS 1000 becomes acceptable if it has a custom, weaker PC, etc.) I guess in short, it has to be blasters that can be competitive (and not overpowering) against PR "pistol" class blasters.
I will try to host more of these "light blasters only" games, and that may give me a better idea of what games work well for 2012+ only blasters' games, because the performance range is very similar. However, the "2012+ only" category is heavily split into two distinct performance groups as pointed out earlier, and I will only be able to focus on the WW + HydroCannon group). Sure, I have the money to stock up on cheap, low performance piston pumpers and squirters, in order to simulate how a Nerf SS squirter game would go, but I don't find that to be worth my time; too boring and not enough variety. It's not about elitism or snobbery, it's about what's worth our time and money, and I think most of us do not want to waste that on the Nerf SS line even if it was under the guise of being an outreach effort. (The only exception would be to organize to attend Nerf SS events and play using our standard blasters, but do it in a way that doesn't result in bad PR. Heh, that abbreviation has two uses in the community now.)